Overview

Overview

This dashboard is for HDX data for BF2-B15:01 and B2-B19:01 +/- peptide

  • This tab will contain the mean uptake per timepoint overlaid onto the structures as animations.

  • The second tab has heatmaps comparing peptide free to peptide bound for each allotype, providing a measure of peptide dependent exchange.

  • The third and fourth tabs compare allotypes peptide free and peptide bound to give a measure of allotype dependent exchange using the mean HDX across overlapping peptides for each timepoint.

  • The fifth and six tabs show the HDX maps of the individual peptides. You may need to zoom in to see the peptides clearly.

Peptide dependent exchange

HDX exchange values for Peptide bound vs. Peptide free. Negative values (red) represent % greater exchange in the peptide free, 0 no difference (blue), and positive values (white) represent % less exchange in the peptide free than peptide bound.

Column

BF2*15:01 Heavy Chain +/- peptide

BF2*15:01 B2m +/- peptide

Column

BF2*19:01 Heavy Chain +/- peptide

BF2*19:01 B2m +/- peptide

Allotype dependent Heavy chain exchange

HDX exchange values +/- peptide as a percentage of maximum theoretical exhange.

Column

BF2*15:01 Heavy chain + peptide

BF2*15:01 Heavy chain - peptide

Column

BF2*19:01 Heavy chain + peptide

BF2*19:01 Heavy chain - peptide

Allotype dependent \(\beta_{2}\)m exchange

HDX exchange values +/- peptide as a percentage of maximum theoretical exhange.

Column

BF2*15:01 \(\beta_{2}\)m + peptide

BF2*15:01 \(\beta_{2}\)m - peptide

Column

BF2*19:01 \(\beta_{2}\)m + peptide

BF2*19:01 \(\beta_{2}\) - peptide

Heavy chain peptide maps

HDX exchange values +/- peptide as a percentage of maximum theoretical exhange.

Column

BF2*15:01 Heavy chain + peptide

BF2*15:01 Heavy chain - peptide

Column

BF2*19:01 Heavy chain + peptide

BF2*19:01 Heavy chain - peptide

\(\beta_{2}\)m peptide maps

HDX exchange values +/- peptide as a percentage of maximum theoretical exhange.

Column

BF2*15:01 \(\beta_{2}\)m + peptide

BF2*15:01 \(\beta_{2}\)m - peptide

Column

BF2*19:01 \(\beta_{2}\)m + peptide

BF2*19:01 \(\beta_{2}\)m - peptide